摘要
目的 检测COX- 2和VEGF在膀胱移行细胞癌(TCC)中的表达,分析表达结果与组织分级、临床分期的关系及其相关性。方法 采用免疫组织化学法对4 1例膀胱移行细胞癌存档蜡块中的COX -2和VEGF进行检测。结果 4 1例TCC组织中COX 2和VEGF的阳性表达率分别是6 8%、6 1% ,正常膀胱粘膜中(n =6 )没有表达,提示COX 2和VEGF的表达与肿瘤的病理分级、临床分期有关(P <0 .0 5 ) ,COX -2和VEGF成正相关性(P <0 .0 5 )。结论 COX- 2和VEGF在TCC的发生、发展中起重要作用,二者在血管的生成中密切相关,可能为TCC治疗提供新靶点。
Objective To investigate the expression of cyclooxygenase-2 (COX-2) protein and vascular endothelial growth factor(VEGF) in bladder transitional cell carcinoma(TCC),and analyze the correlation between COX-2 and VEGF,the relationship of their protein expression and histopathological gradeclinical stage. Methods The immunohistochemical method was used to determine the expression of COX-2 and VEGF in 41 paraffin embedded samples of TCC,and in 6 normal bladder specimens respectively. Results The percentage of COX-2 and VEGF protein positive expression was 68% and 61% in TCC respectively,no marked expression of their protein in normal bladder. The positive expressions of COX-2 and VEGF were correlated with histopathological grade and clinical stage (P<0.05). There was positive correlation between the expressions of COX-2 and VEGF (P<0.05). Conclusion COX-2 and VEGF protein in TCC play an important role in the tumorgenesis and malignant progress, both have close relation in angiogenesis and may provide new targets for therapy of TCC.
出处
《苏州大学学报(医学版)》
CAS
北大核心
2005年第2期309-311,共3页
Suzhou University Journal of Medical Science