COX-2、VEGF在膀胱移行细胞癌中的表达及其意义

Expression and Implication of Cyclooxygenase-2VEGF in Bladder Transition Cell Carcinoma

目的 检测COX- 2和VEGF在膀胱移行细胞癌(TCC)中的表达,分析表达结果与组织分级、临床分期的关系及其相关性。方法 采用免疫组织化学法对4 1例膀胱移行细胞癌存档蜡块中的COX -2和VEGF进行检测。结果 4 1例TCC组织中COX 2和VEGF的阳性表达率分别是6 8%、6 1% ,正常膀胱粘膜中(n =6 )没有表达,提示COX 2和VEGF的表达与肿瘤的病理分级、临床分期有关(P <0 .0 5 ) ,COX -2和VEGF成正相关性(P <0 .0 5 )。结论 COX- 2和VEGF在TCC的发生、发展中起重要作用,二者在血管的生成中密切相关,可能为TCC治疗提供新靶点。

Objective To investigate the expression of cyclooxygenase-2 (COX-2) protein and vascular endothelial growth factor(VEGF) in bladder transitional cell carcinoma(TCC),and analyze the correlation between COX-2 and VEGF,the relationship of their protein expression and histopathological gradeclinical stage. Methods The immunohistochemical method was used to determine the expression of COX-2 and VEGF in 41 paraffin embedded samples of TCC,and in 6 normal bladder specimens respectively. Results The percentage of COX-2 and VEGF protein positive expression was 68% and 61% in TCC respectively,no marked expression of their protein in normal bladder. The positive expressions of COX-2 and VEGF were correlated with histopathological grade and clinical stage (P<0.05). There was positive correlation between the expressions of COX-2 and VEGF (P<0.05). Conclusion COX-2 and VEGF protein in TCC play an important role in the tumorgenesis and malignant progress, both have close relation in angiogenesis and may provide new targets for therapy of TCC.