急性脑梗死溶栓治疗前后动态检测血清白细胞介素-6的意义

Significance of detecting level of serum interleukin-6 before and after treatment of acute cerebral infarction by dissolution of emobolism

目的:研究急性脑梗死患者溶栓治疗前后血清白细胞介素- 6 (IL - 6 )含量的动态变化及其临床意义。方法:急性脑梗死4 3例按梗死灶大小分成2组,采用双抗体夹心ABC- EL ISA法检测2组患者在治疗前及治疗后第3天、7天、14天血清IL - 6水平。结果:大、小灶性梗死组在脑梗死急性期血清IL - 6均显著高于对照组(P<0 .0 1) ,且大灶性梗塞组明显高于小灶性梗塞组(P<0 .0 5 )。小灶性梗死组治疗后3天血清IL- 6比治疗前明显下降(P<0 .0 1) ;至14天恢复正常(P>0 .0 5 )。大灶性梗塞组治疗后3天血清IL- 6与治疗前相比无明显下降(P>0 .0 5 ) ;7天后比治疗前明显下降(P<0 .0 1) ;但至14天仍高于正常(P<0 .0 1)。结论:动态检测急性脑梗死患者血清IL- 6水平有助于监测病情、观察疗效及判断预后。

Objective:To study the variation in serum interleukin-6 level of patients with acute cerebral infarction and its clinical value before and after they were treated by dissolution of embolism.Methods:According to the size of the infarction,43 patients were divided into two groups.The levels of serum IL-6 in the two groups were examined by using ABC-enzyme-linked immunosorbent assay before and 3,7and 14 days after the patients underwent treatment.Results:The levels of serum IL-6 in the two groups were significantly higher than that of the control group(P<0.01).The large-focus infarction groups was higher than the small-focus infarction one in the serum IL-6 level.The IL-6 level of the small-focus infarction group was obviously lower three days after treatment than before treatment(P<0.05),and the level returned to normal 14 days after treatment(P<0.05).Three days after treatment,there was no significant drop in the serum IL-6 level of the large-focus infarction group.The level was obviously lower after 7 days of treatment(P<0.01),but was still higher than normal 14 days after treatment(P<0.01).Conclusions:Dynamic examination of the serum IL-6 level of acute cerebral infarction patients is beneficial for us to monitor patients' condition,observe therapeutic results and judge prognosis.