血管紧张素转换酶基因插入缺失多态性在宁夏农村回汉族人群中的分布及其与原发性高血压的关系

A study of the I/D polymorphism of angiotensin I converting enzyme gene in the Muslim and Han in Ningxia rural area and the relationship with essential hypertension

目的 研究血管紧张素转换酶(ACE)基因插入缺失多态性在宁夏农村地区回汉族人群中的分布,探讨其与农村回汉族高血压的关系。方法 利用PCR技术对37例农村地区回族高血压患者,4 2例回族正常人,81例同一地区的汉族高血压患者以及34例汉族正常人进行ACEI D基因型的分析比较。结果 宁夏农村地区回族高血压患者的ACE基因I D多态性基因型分布是:Ⅱ型2 7.0 %、ID型2 7.1%、DD型4 5 .9% ,回族正常对照的基因型分布是Ⅱ型31.0 %、ID型2 6 .1%、DD型4 2 .9% ,同一地区汉族高血压患者的基因型分布是Ⅱ型37.0 %、ID型2 3.5 %、DD型39.5 % ,汉族对照组的基因型分布是Ⅱ型5 7.6 %、ID型2 1.2 %、DD型2 1.2 %。结论 宁夏农村地区回族人群的ACE基因I D多态性的基因型分布与同一地区相应汉族人群的分布无显著差异,D等位基因正常汉族高于相应回族人群和汉族高血压组。

Objective To observe the distribution of polymorphism in angiotensinI-converting enzyme gene in the rural area population in Ningxia and to understand the relationship between the polymorphism and the Muslim essential hypertension.Methods An insertion/deletion polymorphism in angiotensinI-converting enzyme gene was detected by PCR in 37 Muslim EH patients,42 normal muslins,34 Han nationalities and 81 Han EH patients.Results In Muslim EH patients the distribution of ACE genotype was II 27.0 %,ID 27.1%,DD 45.9% in normal muslins it was Ⅱ31.0% ID26.1% DD42.9%,in Han EH patients it was Ⅱ37.0% ID23.5% DD39.5 % and in normal Han population it's Ⅱ57.6% ID21.2% DD21.2%.Conclusion There are no significant difference of the distribution of genotype Ⅱ,ID,DD between the Muslims and Han nationalities in rural area of Ning xia ,there are a significant difference of D allele between normal Han and other three groups.