寡核苷酸链在肿瘤反基因疗法中的运用新进展
摘要
反基因疗法是通过寡核苷酸链在dsD N A与蛋白质的结合部位形成三链结构来抑制基因的转录,达到治疗肿瘤的效果。由于天然寡核苷酸链存在易被核酸酶消化、半衰期短、稳定性差、不易透过细胞膜、以及安全性等问题,制约了反基因技术的发展。近年来研制出的硫代寡核苷酸链、肽核酸、锁核酸等修饰物使寡核苷酸链的性能得到了很大提高,为反基因疗法的临床广泛应用提供了理论和实践依据。本文就寡核苷酸链在肿瘤及基因疗法中的运用新近展作一综述。
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