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青霉烯及其代表药物法罗培南的研究进展 被引量:14

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摘要 青霉烯是一类非典型的β内酰胺类抗生素。与其它的β内酰胺类抗生素包括碳青霉烯类相比,其结构明显不同。因其具有广谱的抗菌活性,对β内酰胺酶的高度稳定性,对青霉素结合蛋白的高亲和力等主要特点,而受到广泛关注。其代表药物法罗培南是第一个开发上市的青霉烯类抗生素,对需氧及厌氧性革兰阳性菌、革兰阴性菌均显示出广谱的抗菌活性,是一类新的抗感染药物。对青霉烯类抗生素的结构特点、作用机制、体内外研究等进行综述。
出处 《国外医药(抗生素分册)》 CAS 2005年第3期111-115,共5页 World Notes on Antibiotics
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参考文献20

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二级参考文献10

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