原发性高血压患者颈动脉粥样硬化与AT_1R基因多态性的关系

Carotid atherscleross and angiotensin Ⅱ type 1 receptor gene polymorphism in primary hypertension

目的探讨血管紧张素Ⅱ1型受体(AT1R)基因多态性与原发性高血压颈动脉粥样硬化之间的关系及其发病机制。方法采用盐析法提取150例原发性高血压患者的白细胞DNA,多聚酶链式反应结合限制性内切酶法检测AT1R基因型;彩色多普勒超声测定颈总动脉、颈内动脉,并与100例健康成年人对照。结果原发性高血压患者的AC基因型频率220%,C等位基因频率187%,均比正常健康组高(P<005);随高血压分级增加,颈动脉内膜中层厚度(IMT)逐渐增厚。结论AT1R基因多态性可能是原发性高血压的遗传因素,高血压是颈动脉粥样硬化的重要易感因素。

Objective To study the relationship between angiotensin Ⅱ type 1 receptor (AT_~1 R) gene polymorphism and carotid atherosclerosis and pathogenesis in primary hypertension . Methods Polymerase chain reaction combined with restriction enzyme digestion and ultrasonography were used to measure AT_~1 R gene polymorphism and carotid artery intima-media thickness (IMT) separately in 150 patients with primary hypertension compared with 100 controls . Results The frequencies of AC genotype and C allele of AT_~1 R gene in patients were higher than those of control ^(P<0.05). Carotid artery atherosclerosis was more common in patients with primary hypertension than that of control . Conclusions AT_~1 R gene are associated with primary hypertension .The hypertension is an important factor to promote the carotid artery atherosclerosis.