CD40L在肿瘤治疗中的作用
摘要
CD40L和CD40的相互作用在胸腺依赖的体液免疫和细胞免疫的调控中居于重要地位。研究表明,CD40L具有对肿瘤直接的生长抑制作用和对抗瘤免疫的激活作用。在对CD40L转染细胞诱导的抗肿瘤免疫的研究中,研究者们也取得了一些可喜的成果。这些研究进一步揭示了CD40L在肿瘤免疫治疗方面的应用前景。
出处
《国外医学(免疫学分册)》
2005年第3期162-166,共5页
Foreign Medical Sciences(Section of Immunology Foreign Medical Sciences)
参考文献20
-
1Tong AW, Stone MJ. Prospects for CD40-directed experimental therapy of human cancer[J]. Cancer Gene Ther,2003,10(1): 1-13.
-
2Roselli M, Mineo TC, Basili S, et al. Soluble CD40 ligand plasma levels in lung cancer[J]. Clin Cancer Res,2004,10(2) :610-614.
-
3Jeurissen A,Wuyts M,Kasran A,et al. Essential role for CD40 ligand interactions in T lymphocyte-mediated modulation of the murine immune response to pneumococcal capsular polysaccharides [ J]. J Immunol, 2002,168(6) :2773-2781.
-
4Higuchi T, Aiba Y, Nomura T, et al. Cutting Edge: Ectopic expression of CD40 ligand on B cells induces lupus-like autoimmune disease[J]. J Immunol,2002,168( 1 ) :9-12.
-
5Fujii S,Liu K,Smith C, et al. The linkage of innate to adaptive immunity via maturing dendritic cells in vivo requires CD40 ligation in addition to antigen presentation and CD80/86 costimulation[ J]. J Exp Med,2004,199(12): 1607-1618.
-
6Ghamande S, Hylander BL, Oflazoglu E, et al. Recombinant CD40 ligand therapy has significant antitumor effects on CD40-positive ovarian tumor xenografts grown in SCID mice and demonstrates an augmented effect with cisplatin[J]. Cancer Res,2001,61 (20): 7556-7562.
-
7Friedlander PL, Delaune CL, Abadie JM, et al. Efficacy of CD40 ligand gene therapy in malignant mesothelioma[J]. Am J Respir Cell Mol Biol,2003 29(3): 321-330.
-
8Airoldi I, Lualdi S, Bruno S, et al. Expression of costimulatory molecules in human neuroblastoma. Evidence that CD40 + neuroblastoma cells undergo apoptosis following interaction with CD40L [ J ]. Br J Cancer, 2003, 8810): 1527-1536.
-
9Xiang R, Primus FJ, Ruehlmann JM, et al. A dual-function DNA vaccine encoding carcinoembryonic antigen and CD40 ligand trimer induces T cellmediated protective immunity against colon cancer in carcinoembryonic antigen-transgenic mice [ J ]. J Immunol, 2001,167 (8): 4560-4565.
-
10Zhang L,Tang Y, Akbulut H, et al. An adenoviral vector cancer vaccine that delivers a tumor-associated antigen/CD40-ligand fusion protein to dendritic cells[J]. Proc Natl Acad Sci U S A, 2003, 100(25): 15101-15106.
-
1任明强,陈琦.非霍奇金淋巴瘤血浆中sCD40L检测及意义[J].肿瘤防治研究,2009,36(7):587-589. 被引量:4
-
2胡荣,朱珂,李佳,苗苗,杨莹,刘卓刚.B细胞非霍奇金淋巴瘤中CD40和NF-κB表达及意义[J].临床与实验病理学杂志,2013,29(2):131-133. 被引量:7
-
3吴红兵,田聆,王虎,文艳君,魏于全,郑广宁.腺病毒介导的人CD40配体基因抑制裸鼠卵巢癌生长的实验研究[J].现代预防医学,2008,35(9):1736-1737.
-
4朱晋峰,王少元.CD40配体在肿瘤免疫治疗中的机制研究[J].国外医学(内科学分册),2006,33(7):298-300. 被引量:2
-
5陈凌,廖晓龙.CD40配体在肿瘤免疫治疗中的应用[J].国外医学(肿瘤学分册),2004,31(8):584-587.
-
6李维,杨松,张伶,涂植光.VEGF对白血病树突状细胞诱导CTL杀伤活性的影响[J].中国输血杂志,2008,21(5):342-345.
-
7罗龙龙,张彦,侯春梅,乔春霞,黎燕.抗CD40单克隆抗体研究进展[J].中国实验血液学杂志,2013,21(2):508-512. 被引量:3
-
8穆传勇,陈成,庞雪芹,瞿秋霞,刘慧,黄建安.非小细胞肺癌组织和患者外周血中CD40的表达及其临床意义[J].苏州大学学报(医学版),2012,32(6):841-844. 被引量:1
-
9任明强,陈琦,苏俊.弥漫性大B细胞淋巴瘤中CD40L的表达及意义[J].贵州医药,2010,34(6):486-488. 被引量:1
-
10任明强,陈琦,李佑福.非霍奇金淋巴瘤中CD40、CD40L的表达及意义[J].贵州医药,2010,34(4):294-297.