血管内皮生长因子在前列腺癌中的表达及与肿瘤微血管密度和肿瘤细胞增殖的关系

Expression of vascular endothelial growth factor in tissues of prostatic carcinoma and its correlation with microvessel density and cancer cell proliferation

目的探讨血管内皮生长因子(VEGF)在前列腺癌中的表达及与肿瘤微血管密度(MDV)和肿瘤细胞增殖的关系。方法采用免疫组织化学S-P法测定42例前列腺癌组织和10例正常前列腺组织中VEGF、KI-67的表达和MVD计数。结果前列腺癌中VEGF的阳性表达率为77.78%,KI-67LI和MVD计数分别为12.67±4.12和37.23±9.76,VEGF表达水平与肿瘤恶性程度、KI-67标记指数和MDV计数呈正相关。结论VEGF有促进肿瘤细胞增殖及血管生成的作用,联合检测VEGF、KI-67和CD34可作为病理诊断的补充,对患者预后判断和治疗方案的选择有重要参考价值。

Objective: To investigate the expression of vascular endothelial growth factor(VEGF) in tissues of prostatic carcinomas and its correlation with microvessel density(MVD) and cancer cell proliferation. Methods: Expression of VEGF, KI-67 and CD_~34 were detected by immunohistochemical S-P technique in tissues of 42 cases of prostatic carcinomas(PC) and 10 cases of normal prostate(NP).Results:The positive rate of VEGF was 77.78%,KI-67LI (KI-67 labeling index) and MVD were 12.67±4.12 and 37.23±9.76 respectively and the expression of VEGF had positive correlation with the grade of cervical carcinoma, KI-67LI and MVD. Conclusion:VEGF play a role in cancer cell proliferation and tumor angiogenesis.Evaluating VEGF, KI-67 and CD_~34 is the supplement of pathological diagnosis and is important for evaluating the patient's prognosis and selecting suitable therapy.