N-(3-苯基-2,3,4-三唑甲酰基)-N′-酰氨基硫脲的合成

Synthesis of N-(3-Phenyl-2,3,4-triazole formyl)-N′-acylthiosemicarbazides

以2 苯基1,2,3 三唑4 甲酸为原料,经酰氯化,得到2 苯基1,2,3 三唑4 甲酰氯,在PEG 400为相转移催化剂的条件下,与硫氰酸铵及酰肼反应,一锅法合成了一系列新的N (3 苯基2,3,4 三唑甲酰基) N′酰氨基硫脲。研究了合成反应的条件。标题化合物经元素分析、IR、1HNMR确证结构。

One-pot reaction of 2-phenyl-1,2,3-triazole-4-formyl chloride with ammonium thiocyanate and acylhydrazine in the presence of polyethylene glycol-400 (PEG-400) as the PTC catalyst yielded a series of new N-(3-phenyl-2,3,4-triazole formyl)-N′-acylthiosemicarbazides. The reaction conditions were investigated. The structures of these compounds were confirmed by elemental analysis, IR and ()~1H NMR.