胡枝子总黄酮治疗大鼠微小病变型肾病综合征的实验研究

Experimental study on treatment of minimal change nephropathy with Lespedeza Michx

目的:探讨胡枝子对微小病变型肾病的治疗作用,为其开发利用提供实验基础。方法:利用尾静脉注射阿霉素复制大鼠微小病变型肾病模型,观察胡枝子总黄酮对模型2 4h尿蛋白、血清超氧化物歧化酶(SOD)活性、总抗氧化能力(ATCO) ,丙二醛(MDA) ,IL -8,TNF -α含量的影响及对肾组织的病理改变。结果:胡枝子总黄酮能降低尿蛋白含量,提高SOD活力及ATCO能力而降低血中MDA ,并抑制IL -8,TNF -α的分泌。结论:胡枝子总黄酮对大鼠微小病变型肾病综合征有一定治疗作用。

Objective: To study the therapeutic effect of Lespedeza Michx in experimental rat model of minimal change nephropathy (MCN). Method: The rat MCN model was reproduced by tail-intravenous injection of Adriamycin. The treatment effect of Lespedeza Michx was determined by the detection of urine protein collection for 24 hours, malondialdehyde (MDA), superoxide dismutase (SOD), ATCO, IL-8, TNF-α in serum, and renal histopathological changes were observed by microscope. Result: Lespedeza Michx could decrease the contents of urine proteinuria, MDA, IL-8, and TNF-αin serum, increase SOD level and improved the pathological change of glomeruli. Conclusion: Lespedeza Michx was effective on MCN.