刺五加注射液对肺癌患者血NKC,TNF活性的影响及临床意义

Effect of Acanthopanax senticosus injection on the activities of human tumornecrosis factor and natural killer cell in blood in the patients with lung cancer

目的:探讨刺五加注射液(ASI)对肺癌患者外周血自然杀伤细胞(NK)与肿瘤坏死因子(TNF)的影响及机制。方法:将73例肺癌患者随机分成2组即治疗组(n =39,注射ASI)和观察组(n =34,不用任何免疫调节剂)。另选6 1例对照组(对照A组30例为非癌胸病患者,对照B组31例为正常人)。检测TNF和NK细胞活性及免疫球蛋白(IgG ,IgA ,IgM)。结果:治疗后治疗组TNF -α活性水平与两对照组相当,显著低于观察组,TNF- β和免疫球蛋白均显著高于观察组和两对照组(P <0. 0 1)。NK细胞活性治疗组显著高于观察组和两对照组。结论:认为ASI对细胞免疫及细胞因子的产生有调控作用,可用为肺癌患者免疫调节辅助药。

Objective: To study the effect of Acanthopanax senticosus injection (ASI) on the activities of human tumor necrosis factor (TNF) and natural killer cell (NKC) in the patients with lung cancer and the underlying mechanism. Method: 73 cases with lung cancer were randomly divided into two groups, namely, the treatment group (n=39) and observation group (n=34); 61 cases with or without other diseases were respectively divided into control A (n=30) and B (n=31) groups. The patients in treatment group were injected with ASI for 21 days. The activities of human TNF and NKC and the levels of IgG, IgA and IgM were detected respectively. Result: After injection with ASI the activity of TNF-α in treatment group was comparable with that in the two control groups and was significant lower that that in observation group. The activity of TNF-β and the levels of IgA, IgG and IgM were significantly higher than those in observation group and two control groups(P<0.01). The activity of NKC was also remarkably higher than observation and two control groups. Conclusion:ASI can regulate the cellular immunity and factor, indicating that ASI can be used as an assistant drug to regulate the function of cellular immunity in the patients with lung cancer.