盐酸伪麻黄碱生产工艺改革

Improvement of the process of producing pseudoephedrine hydrochloride

目的:探讨盐酸伪麻黄碱生产新工艺流程,以解决长期存在的产品质量问题。方法:在研究精制伪麻黄碱的基础上,由伪麻黄碱制备盐酸伪麻黄碱。确定合成条件,考察产品质量和产率。结果:新工艺盐酸伪麻黄碱具良好稳定性,解决了产品结块问题,且较原工艺的产量有所提高。结论:在原生产工艺基础上的改革有生产应用价值。

Objective: To improve the design of the technological process so as to solve the long existing quality problem in the process of producing pseudoephedrine hydrochloride. Method: Pseudoephedrine hydrochloride was developed on basis of developing pseudoephedrine. And its preparation condition was observed. Result: Pseudoephedrine hydrochloride obtained in the improved process didn′t show tendency to agglomerate, which solves the quality problem of the product and the rate of production was raised. Conclusion: The improved process of producing pseudoephedrine hydrochloride has great apptication value.