鞘内注射罗氏芬治疗颅内感染疗效观察

Effect of intrathecal injection with Rocephin on intracranial infection

目的观察鞘内注射罗氏芬治疗颅脑损伤后颅内感染的疗效。方法对12 例颅脑损伤后颅内感染患者给予罗氏芬2.0 g静脉推注,每日2次;罗氏芬0.1 g加生理盐水10 ml鞘内注射,每日1 次。治疗前行脑脊液细菌培养及药敏检查,根据药敏结果更换抗生素。结果经罗氏芬治疗后,12例患者痊愈6例、显效2例、进步1例、无效3例,显效率66.7%;脑脊液中白细胞数及蛋白含量明显降低,糖和氯化物明显升高,颅内压明显降低。12例患者的脑脊液中分离出细菌12 株,细菌阳性率100%;治疗后8例菌株被清除,细菌清除率66.7%。治疗中未出现与罗氏芬有关的不良反应。结论罗氏芬静脉和鞘内注射治疗颅脑损伤后颅内感染临床疗效较好。

ObjectiveTo observe the effect of intrathecal injection with Rocephin on intracranial infection after traumatic brain injury.Methods12 patients with intracranial infection after traumatic brain injury were treated with Rocephin, including Rocephin 2.0 g vein injection twice a day and 0.1 g intrathecaluse once a day. The germiculture and drug sensitivity test were made before the treatment and antibiotic was selected.ResultsThere were 6 cases recovered, 2 cases improved markedly, 1 case improved and 3 cases unchanged. The efficient rate was 66.7%. The examination of cerebrospinal fluid showed that the levels of leucocyte and protein decreased, the glucose and chloride increased and encephalic pressure declined. 12 bacteria were verified in 12 cases and 8 bacteria were eliminated after treatment. The bacterium cleared rate was 66.7%. There were no side effects correlatives with Rocephin.ConclusionVein and intrathecal injection with Rocephin is effective on intracranial infection after traumatic brain injury.