N,O-羧甲基壳聚糖的制备

Preparation of Carboxymethyl-chitosan

本文研究了在碱性条件下,用氯乙酸对壳聚糖进行化学改性,合成了有良好水溶性的N,O 羧甲基壳聚糖。实验结果表明:壳聚糖、氢氧化钠、氯乙酸三者质量之比为1∶4∶4. 5,温度为60℃,反应时间为5h时,所得羧甲基壳聚糖的取代度达到1. 18,产率为145%。

To prepare good water-solubility N,O-Carboxymethyl chitosan(N,O-CMC) ,chitosan is modified with chloroacetic acid in the presence of sodium hydroxide. The result indicates that when the weight ratio of chitosan,sodium hydroxide and chlorethanonic acid is 1 ∶ 4 ∶ 4.5,reaction temperature is 60 ℃,and reaction time is 5 hours, the substitution degree of N,O--CMC is 1.18 ,the yield of CMC is 145%.