静脉注射用丙种球蛋白治疗新生儿ABO溶血病对血清免疫球蛋白的影响

Clinical observation of the effect of intravenous Immunoglobulin on serum immunoglob- ulin of the ABO hemolysis newborn

目的通过新生儿ABO溶血病使用静脉注射用丙种球蛋白(IVIG)前后的血清免疫球蛋白指标变化观察,探讨IVIG使用对新生儿血清免疫球蛋白的影响。方法随机将新生儿ABO溶血症患儿分为两组,常规治疗+IVIG为治疗组,常规治疗为对照组,IVIG治疗剂量为800-1000mg/kg,分别测定使用IVIG前,使用IVIG后2d、28d、2个月体内血清免疫球蛋白数值并与对照组对照。结果治疗组IgG、IgM在用药后2d、IgA在用药后28d与对照组比较差异有显著性,其余指标两组差异无显著性。结论IVIG治疗新生儿ABO溶血病不会使新生儿IgG的合成受抑制,但使IgM、IgA的合成在短期内受到抑制。

Objective To examine the effect of using Intravenous Immunoglobulin (IVIG) on the serum immunoglobulin of the ABO - hemolysis newborn. Methods All of the chosen ABO - hemolytic disease newborn infants were divided randomly into two groups, A group (experimental group, which was given both regular therapy and IVIG) and B group ( control group, which was given only regular therapy) . The dose of IVIG was 800 0 1000 mg/ kg. The values of serum immunoglobulin were compared between two groups before using IVIG, and 2, 12, 28 days and 2 months after using IVIG. Results The serum IgG level in A group was dramatically higher than that of B group on the 2nd day after using IVIG. The serum IgM level in A goup was dramatically lower than that of B group on the 2nd day after using IVIG. The serum IgA level in A group was dramatically lower than that of B group on the 28th day after using IVIG. Conclusion The usage of IVIG on ABO-hemolytic disease newborn infants doesn't inhibit the self-synthesis of IgG by the newborn, the self-synthesis of IgM and IgA may be inhibited in short period.