PSS患者血浆纤维蛋白降解产物－D二聚体的检测

Plasma Fibrin Degradation Products-D Dimer Inspected in Patients with Progressive Systemic Sclerosis

ＥＬＩＳＡ法检测１３例ＰＳＳ患者血浆ＤＤ水平，其浓度增高（Ｐ＜０．０５），并与血浆ＴＡＴ是显著正相关（Ｐ＜０．０５），得回归方程，但与血浆ＰＩＣ无关（Ｐ＞０．０５）。提示患者交联性纤维蛋白降解加速，纤溶作用增强，反映了凝血、纤溶系统活化。

Fibrin degradation products-D dimer(FDP-DD) inplasma was inspected by an enzyme linked immunosorbent assay (ELISA) in patients with progressive systemic sclerosis (PSS). FDP-DD in plasma was higher(p< 0. 05 ) and related to thrombin-antithrombin Ⅲ(TAT) complex in plasma (P<0. 0005) and was notassociated with Plasmin-α2 plasmin inhibitor complex(PIC) in plasma(p>0. 05) in these patients. This suggested that the degradation of cross-linked fibrin wasaccelerated and fibrinolysis was strengthened, and thatthere were activated coagulation and fibrinolysis systems, enhanced effects as well as changed dynamic balance in the PSS patients.