摘要
目的:研究抗精神病药物对糖代谢的影响,以期为临床用药提供参考。方法:根据入组条件选定465例研究对象,测定其血糖,并用统计方法处理。结果:精神病人糖尿病发生率为3 68%,糖代谢异常发生率为9 89%,第1代抗精神病药糖代谢异常发生率高于第2代抗精神病药物。结论:抗精神病药物对糖代谢均有所影响,临床应用中应尽可能用糖代谢异常较小的药物,做到合理用药,以减少不良反应。
OBJECTIVE:To study the effect of antipsychotic on glycometabolism, in order to provide some references for clinical drug use. METHODS: 465 patie nts were selected for studying. Their blood sugar was determined, the results were dealt with by statistics. RESULTS: The incidence of diabetes in the patie nts with mental disorders was 3.68%, the incidence of abnormal glycometabolism was 9.89%. The incidence of abnormal glycometabolism induced by 1st generation antipsychotic was higher than that induced by the 2nd one. CONCLUSION: Since a ntipsychotic has some adverse effect on glycometabolism, so it is better to use drugs with less adverse effect on glycometabolism and use drugs rationally, in order to reduce adverse reactions.
出处
《中国医院用药评价与分析》
2005年第2期97-100,共4页
Evaluation and Analysis of Drug-use in Hospitals of China
