大鼠冠状动脉结扎心肌缺血模型方法的改进

An improved myocardial ischemia model by rat coronary artery ligature

目的:改进结扎大鼠冠状动脉心肌缺血模型的制作方法。方法:通过生存率、实验结果稳定性和手术时间的观察,比较两种大鼠心肌缺血模型的制作方法。结果:改进后的模型制作方法在不改变大鼠生存率和结果稳定性的条件下,缩短手术时间。结论:改进后的模型制备方法具有显著优越性。

Objective:To re-establish myocardial ischemia model by coronary artery ligature in rats. Methods: Two procedures to establish rat myocardial ischemia models were compared using postmodel survival rate,operation length and the data reproducibility. Results: The operation length of the new model was shorter than that of former one, while post-model survival rate and the data reproducibility were not impacted. Conclusion: The improved myocardial ischemia model offers significant superiority to the former one.