卢帕他定的合成

Synthesis of rupatadine

目的:合成卢帕他定。方法:以氯雷他定为原料,经水解、烷基化2步反应合成卢帕他定。结果:合成了卢帕他定,总收率32.4%。结论:本方法可以方便地得到卢帕他定,简化了操作,缩短了反应周期。

Objective:To synthesize rupatadine. Methods:Rupatadine was prepared from loratadine via hydrolysis and alkylation. Results:The total yield of rupatadine was 32.4%. Conclusion: The synthetic route for rupatadine was simplified.