鱼腥草素钠(粉针剂)体外抗菌活性的初步研究

Initial Study on Sodium Houttuyfonate(injectable powder) Antimicrobial Activity in Vitro

目的:测定鱼腥草钠(粉针剂)对临床常见致病菌的抗菌能力,以期评价其体外抗菌效果,为该药物粉针剂的开发和临床研究提供依据。方法:使用微量液体稀释法和琼脂稀释法测定鱼腥草素钠(粉针剂)不同条件下对临床常见致病菌最小抑菌浓度(MIC)和最小杀菌浓度(MBC)。结果:鱼腥草素钠(粉针剂)对革兰阴性杆菌(肺炎克雷伯菌、大肠埃希菌)和真菌(白色念珠菌)抗菌效果较差,MIC>10 2 4μg/ ml。对革兰阳性球菌(金黄色葡萄球菌、表皮葡萄球菌及肺炎链球菌)有较好抑制作用,其MIC在6 4μg/ ml左右,不同p H值和不同菌液浓度对鱼腥草素钠(粉针剂)的抗菌效果无明显影响。结论:鱼腥草素钠(粉针剂)对革兰阳性球菌(金黄色葡萄球菌、表皮葡萄球菌及肺炎链球菌)有较好抑制作用,值得进一步开发和利用。

Objective:To evaluate Sodium Houttuy fo nate (injectable powder)antisepticize effect by determination antimicrobial acti vity in vitro which may be helpful to exploitation and clinical research.Methods:MIC and MBC were determined by microamount liquid dilution method and agar dilution method under different conditions.Results:It is not effective to gram negative bacilli and i s effective to gram positive coccus. Antimicrobial activity was not effective in different conditions.Conclusion:The gram positive coccus can be inhibited by So dium Houttuyfonate (injectable powder), which is value of further development an d utilization.