抑郁症、焦虑症、强迫症患者睡眠脑电图及P_(300)的比较

The comparison study of polysomnography and P_(300) in patients with depression, anxiety disorder or obsessive-compulsive disorder

目的 探讨抑郁症、焦虑症、强迫症患者睡眠脑电图的差异及其与事件相关诱发电位P300关系。方法 对31例抑郁症、20例焦虑症、20例强迫症患者进行多导睡眠脑电图和P300测定,将3组的多导睡眠脑电图结果与P300各指标进行相关分析。结果 ( 1 )抑郁症、焦虑症、强迫症3组睡眠进程各个指标的差异均无统计学意义; (2)与焦虑症组和强迫症组比较,抑郁症组快速眼动(REM)睡眠的活动量小、强度低、睡眠时间少,睡眠周期数少、睡眠结构中REM睡眠比率均低,而睡眠结构的第1阶段比率高(P<0 01和<0 05);焦虑症组与强迫症组间睡眠脑电图各项指标的差异无统计学意义; (3)各组睡眠脑电图的各项指标与P300存在不同的相关性。结论 抑郁症与焦虑症、强迫症睡眠结构比率和REM睡眠的特点不同,关注睡眠特别是REM睡眠的神经机制可能会进一步认识认知功能的改变。

Objective The present study was to investigate the variations of polysomnography and relationship between polysomnography and P 300 in patients with depression, anxiety disorder or obsessive- compulsive disorder (OCD) , and to analyze the relationship between cognitive deficit and sleep among them.Methods Thirty-one patients with depression, twenty with anxiety disorder, twenty with OCD were involved. The polysomnography, event-related potentials P 300 were measured.Results The depressive patients showed significant difference of rapid eye movement (REM) sleep time, REM activity, REM strength, the percentage of stage 1 sleep compared with anxiety disorder, OCD. No difference was found in each index of polysomnography between patients with anxiety disorder and OCD. The quality of REM sleep is easier to influence the cognitive function in depression than anxiety disorder and OCD.Conclusion May be the study of polysomnography can offer the biological evidence of identified diagnosis among these three diseases. We should study the neuromechanism of sleep, especially REM sleep in order to improve cognition.