当归及其成分阿魏酸对小鼠免疫功能的影响

The Effect of Dang- Gui( Angelica Sinensis)and Ferulic Acid on Mice Immune System

本文研究了当归及阿魏酸对小鼠免疫功能的影响,结果表明:当归(给药剂量分别为15g/kg和30g/kg)与阿魏酸(给药剂量分别为12.5mg/kg和25mg/kg)可明显地增加小鼠脾脏和胸腺重量,促进小鼠腹腔巨噬细胞吞噬功能、小鼠碳粒廓清速率、由SRBC致敏的小鼠血清溶血素的形成、小鼠抗体生成细胞的形成等.当归(剂量为3.25mg/ml)与阿魏酸(0.12mg/ml)可促进ConA诱导的小鼠脾淋巴细胞的增殖,其刺激指数分别为1.47和1.98.说明当归和阿魏酸对非特异性免疫、体液免疫和细胞免疫功能均有较强的促进作用.

The effect of Dang-gui(Angelica sinensis) and Ferulic acid on mice immune system was studied. The results showed that the Dang-gui (with the doses of 15 g/kg and 30 g/kg) and Ferulic acid (with the doses of 12. 5 mg/kg and 25 mg/kg)increased the thymus and spleen weights、 the phogocyto-sis of macrophage、 the clearance rate of carbon particles、 the production of hemolysis and the response of lymphoid cells immune to sheep red cells by ig adminstration for 7 d in mice. Dang-gui (with the dose of 3. 25 mg/ml) and Ferulic acid (with the dose of 0. 12 mg/ml) also showed effects on the murine spleen lymphocyte proliferation by ConA stimulation.