摘要
目的:研究京尼平苷对类风湿性关节炎大鼠血清IL1β和TNFα的影响,进一步探讨该药物的作用机制。方法:建立Ⅱ型胶原蛋白诱导大鼠类风湿性关节炎模型。观察京尼平苷对实验性大鼠足肿胀的抑制作用;检测血清IL1β和TNFα的水平。结果:与模型组比较,京尼平苷可以延缓对侧肢体足肿胀发生的时间,抑制大鼠足肿胀的程度(P<0.01);用药后,中、高剂量给药组血清IL1β和TNFα水平明显低于模型组(P<0.01)。结论:京尼平苷在类风湿性关节炎大鼠中可以下调致炎因子IL1β和TNFα的水平,提示这可能与该药抑制实验性类风湿性关节炎病情进展密切相关。
Objective: To study the effect of geniposide on serum IL-1β and TNF-αlevels of rheumatoid arthritis rats, as well as the mechanism of this drug. Method: To establish an experimental rat model of type Ⅱ collagen-induced arthritic (CIA). The inhibitory effects on paw edema were observed, and serum IL-1β and TNF-α levels were determined in experimental rats. Result: Compared with the model, geniposide delayed the starting time of right paw edema significantly, and the levels of serum IL-1β and TNF-α were significantly decreased by geniposide at high dose or medium dose(P<0.01). Conclusion: Geniposide can lower serum IL-1β and TNF-α levels in rheuma-toid arthritis rats. The effect may be close related to inhibitory development of rheumatoid arthritis by the agent.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2005年第9期708-711,共4页
China Journal of Chinese Materia Medica
基金
武警部队科研基金资助课题(200054)
