绿茶与子宫内膜癌关系的病例对照研究

Green tea consumption and the risk of endometrial cancer: a population-based case-control study in urban Shanghai

目的探讨饮茶特别是绿茶与子宫内膜癌的关系。方法采用以人群为基础的病例对照研究,调查上海市1997年1月至2002年12月间已确诊年龄30～69岁的子宫内膜癌患者(n=995)和全人群对照(n=1087)的一般情况、月经生育史、饮食及营养素、个人生活习惯、激素相关因素、疾病及家族史等资料,采用非条件logistic回归模型分析饮茶与子宫内膜癌的关系。结果与从未饮茶者相比,有饮茶史者患子宫内膜癌的危险略降低(OR=0.82,P=0.0466)。饮茶主要对绝经前女性有保护作用(OR=0.74,95%CI:0.54～1.01);以从不饮茶者为参比组,饮淡茶、浓淡适中及浓茶者的OR值分别为0.72、0.88和0.44,趋势检验有统计学意义(P=0.0431)。在不吸烟不饮酒者中,饮绿茶对子宫内膜癌有保护作用(OR=0.77,P=0.0199);每周饮绿茶频率越高,患子宫内膜癌的危险性越低;以从未饮茶者为参比组,每周饮绿茶<7次及≥7次者OR值分别为0.90(95%CI:0.53～1.54)和0.76(95%CI:0.60～0.95),趋势检验P=0.0163;饮绿茶量越大危险性越低,每月饮绿茶≤100g、～200g及>200g者的OR值分别为0.76、0.87和0.74,趋势检验有统计学意义。结论饮茶特别是绿茶对子宫内膜癌可能有弱的保护作用,且该作用可能局限于绝经前女性。

Objective To assess the effect of tea consumption on the risk of endometrial cancer. Methods In a population based case-control study conducted in urban Shanghai, face-to-face interviews were completed for 995 incidence cases aged 30-69 from January 1997 to December 2002 and 1087 controls that frequency-matched to cases on age. Unconditional logistic model was used for analysis. Results An inverse association was observed in tea drinking and endometrial cancer risk. Compared to non-tea drinkers, regular tea drinkers had reduced risk of endometrial cancer( OR = 0.74 ;95% CI ∶ 0.54- 1.01 ) in premenopausal women. Green tea had a protective effect on endometrial cancer among non-smoking or non-alcohol drinking women( OR = 0.77 , P = 0.0199 ) and the OR s reduced with the increasing concentration of tea being served ( P for trend= 0.0493 ).The multivariate OR s for drinking green tea <7 times/week and ≥7 times/week were 0.90 (95% CI : 0.53- 1.54 ) and 0.76 (95% CI : 0.60- 0.95 ) with the trend test of P = 0.0163 . Conclusion Tea drinking, with green tea in particurla, seemed to have weak but inverse association with endometrial cancer risk, but this effect of protection might only limit to premenopausal women.