急性颅脑损伤患者外周血C-反应蛋白和IL-6水平的动态变化及其临床意义

Dynamic changes of C-reactive protein and interleukin-6 in patients with acute traumatic brain injury

目的:检测急性颅脑损伤后患者外周血C-反应蛋白(CRP)和IL- 6水平的动态变化,探讨其临床意义。方法:选择77例不同病情的急性颅脑损伤患者作为研究对象,32例健康体检者作为对照组。采用免疫浊度法检测血浆CRP,EL ISA法检测IL- 6水平。结果:急性颅脑损伤患者血浆CRP和IL- 6水平均显著高于正常人对照组(P<0 .0 1) ,且患者CRP和IL - 6水平与病情呈正相关;各组患者在入院当天IL - 6和CRP水平有所升高,并在入院1d后继续升高,IL - 6于3d达最高水平,以后逐渐下降,CRP在1d达高峰,随即开始下降;患者IL - 6水平与CRP呈正相关(r=0 .5 5 6 ,P<0 .0 1)。结论:急性颅脑损伤患者外周血IL- 6和CRP水平的变化与病情严重程度密切相关,IL- 6在急性颅脑损伤中可能通过促进肝脏合成CRP,在一定程度上对神经系统起保护作用。

Objective: To observe the dynamic changes of C-reactive protein (CRP) and interleukin-6 (IL-6) in patients with acute traumatic brain injury. Methods: Plasma levels of CRP and IL-6 were determined in 77 patients with acute traumatic brain injury and 32 healthy controls by immuno-nephelometry and ELISA, respectively. Results: CRP and IL-6 contents were significantly higher in brain injury group than those in control group (P<0.01), and correlated with the patient's condition. CRP and IL-6 concentrations increased on the admission day, and peaked on day 1 and 3, respectively. There was a positive correlation between them (r=0.556, P<0.01). Conclusion: CRP and IL-6 levels are related to the severity of patients with acute traumatic brain injury, and IL-6 may protect the nervous system from the damage via improving CRP synthesis in liver.