慢性阻塞性肺疾病患者血气分析与血浆纤维蛋白降解产物的相关性研究

Associations of blood gas analysis and plasma fibrinogen degration products levels in patients with chronic obstructive pulmonary disease

目的 探讨慢性阻塞性肺疾病(COPD)患者血浆纤维蛋白降解产物(FDP)及与血气分析相关性。方法 对30例COPD患者治疗前后血气分析、血浆FDP及30例对照组的血浆FDP分别进行测定。结果 血浆FDP在COPD加重期患者明显升高,与对照组相比有显著性差异(P <0 .0 0 1 ) ;治疗后血浆FDP明显下降,与对照组相比无显著性差异(P >0 .0 5 ) ;血浆FDP与动脉血氧分压(PaO2 )呈负相关(r=- 0 .77,P <0 .0 1 )。血浆FDP与动脉血二氧化碳分压(PaCO2 )呈正相关(r=0 .6 5 ,P <0 .0 1 )。结论 COPD患者存在异常的凝血状态,血浆FDP增高与之有关,低氧血症、高碳酸血症与血浆FDP增高密切相关。

ObjectiveTo evaluate the change of fibrinogen degration products (FDP) and relationship with blood gas analysis in patients with chronic obstructive pulmonary disease (COPD). Methods The FDP level was measured in 30 patients with COPD and in 30 controls. Blood gas analysis was measured in 30 patients with COPD. Results The FDP level was apparently higher in exacerbated patients than that in controls ( P<0.001);After treatment, the FDP level was significantly low, there was no significantly difference compared with controls. The FDP level was negatively correlated with PaO_2. The plasma FDP level was positively correlated with PaCO_2. Conclusions The COPD patients have abnormal coagulation state,elevated FDP level may be associated with hypercoagulability state. Hypoxemia and hypercapnia are negatively related with the elevated FDP level.