摘要
目的:对柠檬烯滴丸的制备工艺进行研究。方法:采用正交实验法研究成型的最佳工艺条件。结果:以PEG4000∶PEG6000(1∶1 5)混合液作为基质,液体石蜡为冷却剂,药物与基质以1∶6配比,料温为70℃,冷却温度为15℃,滴口内外径为2 .0 /2. 4(mm/mm),滴口距冷却液面为4cm,滴速45d/min为最佳条件。结论:该工艺可为柠檬烯滴丸的制备提供实验依据。
Objective: To study the technical preparation of limonene dropping pills. Methods: Orthogonal test was applied to optimize the preparation of limonene dropping pills. Results: The optimized project was as follow: the matrix contained PEG4000∶PEG6000(1∶1.5); the refrigerant was liquid paraffin; the rate of limonene to matrix was 1∶6 and the temperature of limonene w 70℃; the internal and external diameter of burette was 2.0 mm and 2.4 mm, respectively; the burette was 4cm above the surface of refrigerant; drug was dropped into refrigerant of 15℃ at 45 drops per minute. Conclusion: The results provide the data for the ascertainment of shaping operation of limonene dropping pills at the manufacturing scale.
出处
《中药材》
CAS
CSCD
北大核心
2005年第5期418-420,共3页
Journal of Chinese Medicinal Materials