阻塞性睡眠呼吸暂停患者血清肿瘤坏死因子水平及与血脂的关系

The relationship of serum tumor necrosis factor and serum lipid level in patients with obstructive sleep apnea syndrome

目的探讨阻塞性睡眠呼吸暂停综合征(OSAS)患者血清肿瘤坏死因子(TNFα)水平及与脂肪代谢的关系。方法选择OSAS患者58例,单纯肥胖患者21例,分别应用酶联免疫法(ELISA)测定血清TNFα,应用生化酶法测定血脂水平,分析OSAS患者TNFα与血脂以及病情的关系。结果OSAS患者血清TNFα水平〔(291.1±146.2)pmol/L〕高于对照组〔(196.0±86.5)pmol/L〕,血清胆固醇、甘油三酯升高,甘油三酯变化与TNFα水平具有相关性(r=0.575,P<0.01)。结论OSAS患者血清TNFα水平明显升高,并与血脂水平相关。

Objective To explore the change of serum tumor necrosis factor-α (TNF-α) level and serum lipid metabolism in patients with obstructive sleep apnea syndrome (OSAS).Methods 58 patients with OSAS and 21 ones with simplex obese (controls) were selected to determine serum TNF-α with ELISA and lipid levels with biochemical enzyme to analyze the relation of both indexes to state of illness.Results The serum TNF-α level in patients with OSAS 〔(291.1±146.2)pmol/L〕 were higher than that in controls 〔(196.0±86.5)pmol/L〕. And serum lipid level was higher in OSAS patients than that in controls. The change of triglyceride had correlation with TNF-αlevel (r=0.575, P<0.01).Conclusions Serum TNF-α levels in OSAS patients could increase, which has correlation with serum lipid.