疼痛性糖尿病周围神经病变中西医临床治疗研究进展

Progress on Painful Diabetic Peripheral Neuropathy Treated by Integrative Medicine

疼痛性糖尿病周围神经病变(DPN)是一种常见的糖尿病神经系统并发症,缓解疼痛是治疗该病的重点与难点。三环抗抑郁药一直是治疗该病的一线药物,但副反应明显。抗癫痫药及辣椒辣素能缓解糖尿病性神经痛,且副反应较少。近年来开展中医和中西医结合治疗DPN的临床研究,但针对疼痛性DPN的相关报道较少,现就西医西药、中医中药及中西医结合治疗本病疗效综述,提示中西医结合治疗该病是可行的。

The article reviewed clinical studies on painful diabetic peripheral neuropathy (PDPN) treated by integrative medicine. PDPN, a common complication of diabetes mellitus, which could severely influence patients' quality of life. The keystone and difficulty of PDPN treatment is to relieve pain. Tricyclic anti-depressants are the first-line agents for neuropathic pain but with obvious adverse reactions. Antiepileptic drugs and capsicin can relieve PDPN with less adverse reactions. In recent years, lots of report of clinical studies on DPN treated by TCM or integrative medicine were issued, but those pertinent to PDPN were seldom. Only the papers with independent statistical analysis on effect of pain relieving were selected to review in this article, and the authors presumed that it is feasible to treat PDPN with integrative medicine.