山慈菇Cremastra appendiculata化学成分

Studies on chemical constituents from the corm of Cremastra appendiculata

目的:研究人工种植山慈菇的化学成分。方法:采用硅胶柱色谱法分离纯化,薄层色谱比较及波谱法进行结构鉴定。结果:从山慈菇乙醇提取物的醋酸乙酯萃取部分中分离得到6个化合物,鉴定为异赫尔西酚(isohircinol,Ⅰ),4甲氧基菲-2,7-二醇(flavanthrinin,Ⅱ),对羟基苯乙醇(phydroxyphenylethylalcohol,Ⅲ),3,4-二羟基苯乙醇(3,4-dihydroxyphenylethylalcohol,Ⅳ),胡萝卜苷(daucosterol,Ⅴ),β-谷甾醇(β-sitosterol,Ⅵ)。结论:化合物Ⅱ～Ⅵ为首次从该植物中分离得到,化合物Ⅰ为首次从天然资源中分离得到。

Objective:To study the chemical constituents of the corm of the planted Cremastra appendiculata . Method: The compounds were isolated by column chromatography with silica gel and Sephadex LH-20, and their structures were elucidated by means of spectroscopic methods including 2D NMR techniques. Result: Six compounds were isolated, and identified as isohircinol (Ⅰ), flavanthrinin (Ⅱ), p -hydroxyphenylethyl alcohol (Ⅲ), 3,4-dihydroxyphenylethyl alcohol (Ⅳ), daucosterol (Ⅴ), β-sitosterol (Ⅵ). Conclusion: These compounds were not previously isolated from this plant, and isohircinol (Ⅰ) was obtained from natural source for the first time.