摘要
目的:探讨葛根素对大鼠急性脑缺血损伤Hsp70表达的影响。方法:采用闭夹大脑中动脉造成局部脑缺血模型,对脑组织用免疫组化SP法作Hsp70染色,观察其Hsp70表达情况。结果:葛根素干预组Hsp70表达强度显著强于单纯缺血组(P<001)。结论:葛根素有上调大鼠急性脑缺血损伤时Hsp70表达的作用。
Objective: To study the effect of puerarin on the expression of Hsp(heat shock protein)70 in the rats with cerebral injury induced by acute local ischemia. Method: Rat model of acute local cerebral ischemia was made by ligating middle cerebral artery. The Hsp70 expression in brain tissue was detected by SP method of immunohistochemistry. Result: The expression of Hsp70 was significantly higher in puerarintreated rats than those in the rats with cerebral ischemia. Conclusion: Puerarin can enhance the level of Hsp70 expression in the rats with cerebral injury induced by acute local ischemia.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2005年第7期538-540,共3页
China Journal of Chinese Materia Medica
基金
广西壮族自治区卫生厅医药卫生科研课题(Z2001072)
