十二指肠对奥狄氏括约肌运动的调节

Role of the Duodenum on Sphincter of Oddi Motility in Conscious Dogs

目的通过观察清醒状态下十二指肠切除后狗奥狄氏括约肌(SO)运动的变化,检验十二指肠对SO运动的调节作用。方法对照组(n=6)于十二指肠乳头对侧植入测量用套管。十二指肠切除组(n=6)保留十二指肠乳头切除十二指肠,将近端空肠(重建十二指肠)与胃吻合,原十二指肠乳头与重建十二指肠行端侧吻合,再于吻合后的十二指肠乳头对侧植入测量用套管。经套管插入测压管,通过压力变化来观测SO及十二指肠运动变化。结果十二指肠切除后,SO周期性运动消失,SO呈持续性强收缩状态。结论十二指肠对消化间期SO运动有重要的调节作用。

Objective The aim of the present study was to determine the role of the duodenum in controlling sphincter of Oddi(SO) motility using conscious dogs after total duodenectomy. Methods In a control group (n=6), a cannula was implanted into the duodenum opposite to the papilla to allow sphincter of Oddi manometry. In a duodenectomy group (n=6), the papillae were preserved at total duodenectomy and sutured to the jejunum anastomosed to the stomach (neoduodenum). The cannula was implanted opposite to the implanted papillae. Interdigestive and postprandial sphincter of Oddi and duodenal or neoduodenal motility were recorded by manometric and myoelectric methods. Results Duodenectomy disrupted SO cyclic motility. Conclusions During the interdigestive period, the duodenum has a distinct role in regulating sphincter of Oddi cyclic motility.