窒息新生儿的肝功能变化

Changes of Liver Function in Infants with Asphyxia

目的 了解窒息对新生儿肝功能的影响,有助于指导临床新生儿窒息对于重要脏器损害的范围与严重程度判断,指导临床积极治疗。方法 检测6 5例窒息新生儿(12例重度窒息及5 3例轻度窒息)的血清总蛋白(TP)、白蛋白(ALB)、血清总胆红素(TbiL)、直接胆红素(DbiL)、丙氨酸转移酶(ALT)、γ谷氨酰转肽酶(γGT)、碱性磷酸酶(ALP) ,并设30例正常新生儿为对照。结果 窒息后新生儿胆红素出现下降(P <0 .0 1) ,并随窒息程度加重下降愈明显(P <0 .0 1) ;窒息后丙氨酸转移酶出现升高(P <0 .0 1) ,并随窒息程度加重升高愈明显(P <0 .0 1) ;总蛋白(TP)、白蛋白(ALB)、直接胆红素(DbiL)、γ谷氨酰转肽酶(γGT)、碱性磷酸酶(ALP)无明显变化(P >0 .0 5 )。结论 窒息可导致新生儿肝功能损害,尤其对于窒息后血清总胆红素下降与窒息严重程度相关,须引起临床高度重视,故肝功能检测可能可作为Apgar评分的补充。窒息时新生儿肝功能应予以保护,以减轻窒息对于新生儿重要脏器的损害。

Objective To investigate the effect of asphyx ia on the liver function of infants in hope to help to judge the severity and exte nsion of important organ damage in infants with asphyxia and to direct treatment .Methods Total serum protein (TP),alubumin (ALB),total bil irubin (TbiL),aminotransferase (ALT),γ-GT and alkaline phosphatase (ALP) were examined in 65 cases of infants with asphyxia.30 cases of healthy donors were se t as control group. Results TbiL in patients with asphyxia were lower than in healthy donors.The severity of asphyxia was in line with lower TbiL (P< 0. 01).ALT went up during asphyxia,which was higher when severity of asphyxia inc reas ed.In contrast,TP,ALB,γ-GT and ALP showed no change during asphyxia.Conclusion Asphyxia can result in liver function damage i n infants. The severity of asphyxia is associated with TbiL value.Liver function measurement should be supplemented in Apgar score.Protection of liver function is important for asphyxia so as to alleviate organ damage.