格林-巴利综合征247例临床治疗与预后的分析

Clinical therapy and prognosis analysis of 247 patients with GBS

目的 为了更进一步探讨成人格林-巴利综合征(GBS)治疗方法及预后。方法 对1994年～2 0 0 3年我院收治的2 4 7例GBS患者的临床资料进行回顾性分析。结果 地塞米松常规治疗轻型5 4例患者治愈率4 8.2 % ,中型6 0例治愈率31.7% ;甲强龙冲击治疗轻型治愈率6 2 .5 % ,中型治愈率2 8.6 % ;丙种球蛋白治疗中型治愈率5 0 % ,重型治愈率36 %。9例患者死于心脏骤停。结论 激素对轻、中型治疗有一定效果,丙种球蛋白尤其适合重型GBS的治疗。GBS预后较好,心脏骤停是不容忽视的死亡原因。

Objective In order to explore the optimum treatment program and prognosis of adult GBS.Method We performed retrospective analysis of the original data of the 247 patients during the period of 1994-2003.Result In dexamethasone group,the cure rates of 54 patients of light type GBS and 60 patients of medium type were respectively 48.2% and 31.7%.In methylpredninsone group,the cure rates of light and medium type were respectively 62.5% and 28.6%. In human immunoglobulin group,the cure rates of medium and serious type were 50% and 36%.Nine patients died from the cardiac arrest.Conclusion The treatment of hormone had positive effect in light and medium type of GBS.Human immunoglobulin was suitable to serious type particularly.The prognosis of GBS was good.The cardiac arrest was the most non-negligent dead reason.