氟伐他汀干预治疗对不稳定性心绞痛患者介入治疗后炎症因子影响的研究

Effects of fluvastatin on blood levels of inflammatory cytokines in patients with unstable angina undergoing percutaneous coronary intervention

目的 研究氟伐他汀对不稳定性心绞痛冠状动脉介入(PCI)治疗术患者高敏C -反应蛋白(hs- CRP)、肿瘤坏死因子α(TNFα)和肌钙蛋白I(cTnI)的影响。方法 选择2002年7月至2004年4月在我院行冠状动脉介入术的60例不稳定性心绞痛患者为研究对象,随机分为二组:对照组29例,常规药物治疗(抗凝、硝酸酯类、β受体阻断剂、血管紧张素转换酶抑制剂和钙拮抗剂等) 2周;氟伐他汀干预组31例,在常规治疗基础上加用氟伐他汀(商品名来适可)每日40mg治疗2周。分别于药物治疗前、药物治疗后2周(术前当天)及术后24h采集空腹静脉血,测定血清hs -CRP、TNFα和cTnI浓度。结果 药物治疗后,氟伐他汀干预组较对照组血清hs CRP、TNFα和cTnI浓度降低更明显(P<0 .01);氟伐他汀干预组术后血清hs- CRP、TNFα和cTnI浓度明显低于同期对照组(P<0. 01)。结论 冠状动脉介入术后增加血清hs- CRP、TNFα和cTnI水平;氟伐他汀降低冠心病患者血清hs -CRP、TNFα和cTnI浓度;氟伐他汀降低冠状动脉介入术后患者血清CRP、TNFα和cTnI水平。

Objective To investigate the effect of fluvastatin on blood levels of c-reactive protein(CRP), tumor necrosis factor alpha(TNFα) and cardiac troponin I (cTnI) in patients with unstable angina undergoing percutaneous coronary intervention(PCI).Methods Sixty patients who underwent PCI from July 2002 to April 2004 in our hospital were randomized into two groups: control group; fluvastatin group (40 mg/d). Serum levels of CRP, TNFα and cTnI were measured before and after two weeks treatment (in the early morning of the procedure) and at 24 hours after the procedure.Results The serum levels of CRP、TNFαand cTnI in fluvastatin group were distinctly lower than those in control group before(P<0.01)and after the procedure(P<0.01), respectively.Conclusion The result suggested that PCI could lead to a deuectable increase in serum levels of CRP、TNFαand cTnI in patients with coronary heart disease ; Fluvastatin could significantly decrease the serum levels of CRP、TNFα and cTnI in patients with coronary heart disease; Fluvastatin could also decrease the serum levels of CRP、TNFα and cTnI in patients with PCI.