小肠间质瘤预后因素分析

Analysis of prognostic factors in gastrointestinal stromal tumors of the small intestine

目的探讨小肠间质瘤预后相关因素。方法复阅病理切片(苏木精-伊红染色),重新诊断;两点取材构建组织微阵列,免疫组织化学染色检测CD117、CD34、SMA、Desmin、S-100、Ki-67、P53及bcl-2蛋白等8种抗体表达;单因素分析各变量与患者预后的关系。结果58例患者1、3、5年生存率分别为98.3%、69.7%、50.9%。单因素分析,患者预后仅与肿瘤大小及性别有关(P<0.05)。结论对男性小肠间质瘤患者应加以关注,小肠间质瘤直径大于5cm,应高度警惕其复发转移。

Objective To explore the prognostic factors in patients with gas tr ointestinal stromal tumors of the small intestine. Methods Tumor slides stained with hematoxylin and eosin from these patients were reviewed. Two histomorpholog ically representative areas were indentified and arrayed on a tissue microarray. Immunohistochemistry staining were performed using antibodies to detect the exp ression of c kit protein(CD117),CD34,smooth muscle actin,desmin,S 100,Ki 67,P 53 and bcl 2 protein. The relationship between clinicopathologic features and p rognosis was analyzed by univariate analysis. Results The 1 ,3 ,5 year surviv al rate of 58 such patients were 98.3%,69.7%,and 50.9%respectively. The progn osis was related with tumor size and gender by univariate analysis(P< 0.05). Con clusion More attention should be paid to the male patients with small intestine stromal tumors,especially those with tumors size>5 cm,because those tumors are m ore likely to metastasize than smaller tumors(≤5 cm).