血管内皮生长因子D在下咽癌中的表达及其与淋巴结转移的关系

Vascular endothelial growth factor-D expression in hypopharyngeal carcinoma and its relationship with lymphatic metastasis

目的:研究血管内皮因子D(VEGF-D)在下咽癌组织中的表达及其与淋巴结转移的关系。方法:选择64例下咽癌患者的手术切除标本,采用免疫组化染色技术,观察VEGF-D的表达情况。结果:VEGF-D阳性表达率为57.8%(37/64)。根据VEGF-D的染色强度,64例标本被分为阴性组(27例)、局限阳性组(23例)、广泛阳性组(14例),发生淋巴结转移的比例分别为25.9%、78.3%、92.9%,差异有统计学意义(P<0.01)。VEGF-D的表达与淋巴结转移密切相关,与血管转移无相关性。结论:VEGF-D可用来预测下咽癌是否发生淋巴结转移,阻断VEGF-D的表达有可能成为一种新的有效治疗方法。

Objective:To study the relation between expression of vascular endothelial growth factor D (VEGF-D) and lymphatic metastasis in hypopharyngeal carcinoma. Methods:Immunohistochemistry was used to examine the expression of VEGF-D in 64 cases of hypopharyngeal carcinoma. Results:The expression rate of VEGF-D was 57.8%(37/64).According to the intensity of VEGF-D expression, all cases were divided into three groups: negative group(27 cases),focal positive group(23 cases), and diffuse positive group(14 cases),whose rate of lymph node metasesis was 25.9%, 78.3% and 92.9%, respectively. The difference was statistically significant (P<0.01).There was a significant correlation between the expression of VEGF-D and lymphatic metastasis. But the expression of VEGF-D was not related with venous invasion. Conclusions:The presence of VEGF-D in hypopharyngeal cancer may predict lymph node metastasis. In addition, restraining the expression of VEGF-D may be a new therapeutic strategy for hypopharyngeal cancer.