环氧合酶-2在早产产妇胎膜组织中的表达及意义

Expression of cyclooxygenase-2 in fetal membranes of premature delivery

目的:探讨环氧合酶2(COX 2)在早产发病机制中的作用。方法:采用免疫组织化学方法(SP法)检测8例早产临产、10例足月临产及12例足月未临产正常产妇(对照组)宫颈及宫体胎膜组织中COX 2的分布和表达。结果:COX 2在羊膜及绒毛膜上皮细胞和间质细胞中均有表达;早产临产组宫颈及宫体胎膜组织中COX 2表达的免疫组织化学积分均高于足月临产组和对照组(P<0. 05),同时足月临产组也均高于对照组(P<0. 05); 3组产妇的宫颈胎膜与同组宫体胎膜组织COX 2的表达均无统计学意义(P>0. 05)。结论:COX 2可能参与早产分娩的发动,在早产发病机制中起一定作用。

Objective To investigate the effect of cyclooxygenase-2 (COX-2) in pathogenesis of premature delivery. Methods A cross-sectional study was conducted with 30 women in the following categories: preterm delivery in labor with intact membranes( n =8), the term in labor with intact membranes ( n =10), and the term not in labor (control group, n =12). The expressions of COX-2 in different areas of the fetal membranes were examined by immunohistochemical assay. Results The immuoreactivity of COX-2 was found in epithelial cells and stromal cells in amniotic and chorion membranes. Expression of COX-2 in different areas of the fetal membranes varied markedly in preterm delivery in labor, term in labor and the control group. Immunohistochemical scores(IH score) of COX-2 in the cervical and corpus fetal membranes in the preterm delivery in labor group were higher than those in the term in labor group and the control group( P <0.05). There was no difference in COX-2 expression between the cervical and corpus fetal membranes among the three groups ( P >0.05). Conclusion COX-2 may play an important role in the pathogenesis of premature labor.