纤溶酶原激活剂及其抑制剂活性与牙周病活动性的关系

Relationship between Activity of t-PA and PAI in Gingival Crevicular Fluid and Periodontal Disease Activity

目的 研究牙周炎维护期龈沟液(GCF)中组织型纤溶酶原激活剂(t PA)及纤溶酶原激活剂抑制剂(PAI)活性与牙周炎活动期发生的关系。 方法 慢性牙周炎患者牙周基础治疗后1个月,对全口牙进行检查并记录牙周情况。3个月后再次进行复查,筛选出活动期牙位,测定活动期GCF中t PA及PAI的活性,并和邻近非活动期牙位进行比较。 结果 牙周炎活动性的估计年发生率约在8.6 1% ;最常发生牙周炎活动性破坏的是上颌磨牙;牙周炎活动性多见于邻面。非活动性位点与活动性位点之间t PA及PAI的活性、PAI/t PA比值差异均无显著性。 结论 现有的牙周炎活动性诊断标准具有局限性,本研究尚不能确定t PA及PAI活性与牙周炎活动性之间的关系。

Objective To investigate the relationship between activity of tissue plasminogen activator(t-PA) and plasminogen inactivator(PAI) in gingival crevicular fluid(GCF) and periodontal disease activity(PDA). Methods Five chronic periodontitis patients were selected. After initial periodontal therapy, the clinical parameters including attachment loss (AL) were recorded as the baseline datd and then reexamined every three months. Occlusal stents were used for each patient to assure the accuracy and reproductivity of the attachment level measurements. Detection of new attachment loss ≥2 mm between two consecutive visits was designated a site as PDA. The activity of t-PA and PAI in GCF were measured both in the active sites and the adjacent no-active sites. Results The estimated PDA rate per year was 8.61% and the most common active sites were seen in maxillary molars. Datd also showed interproximal sites were more susceptible to PDA. The results also showed that no difference of the activity level of t-PA and PAI in active sites and adjacent no-active sites. Conclusions The present standard to diagnosis periodontal disease activity has limitation. The present research can not determine relationship between activity of t-PA and PAI in gingival crevicular and periodontal disease activity.