摘要
The cytokine-receptor- heparin sulfate functional complex combined by cytokines, cytokine receptors, and heparin sulfate chains formed by concatenation of heparin sulfate proteoglycans (HSPG), an important component of extracellular matrix and modified by some relative enzymes, can regulate the density of cytokine receptors and their intracellular signal transduction. This article focused on the regulatory function of this complex. Many morphological abnormalities and diseases occur when the complex is dysfunctional.
The cytokine-receptor- heparin sulfate functional complex combined by cytokines, cytokine receptors, and heparin sulfate chains formed by concatenation of heparin sulfate proteoglycans (HSPG), an important component of extracellular matrix and modified by some relative enzymes, can regulate the density of cytokine receptors and their intracellular signal transduction. This article focused on the regulatory function of this complex. Many morphological abnormalities and diseases occur when the complex is dysfunctional.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2005年第5期1020-1025,共6页
Chinese Journal of Pathophysiology
基金
国家重大基础研究规划资助项目(No.G1999054204)
国家自然科学基金面上项目(No.30170966)
国家自然科学基金重点项目(No.30230370)
关键词
类肝素硫酸蛋白聚糖
基膜
细胞外基质
Heparin sulfate proteoglycan
Basement membrane
Extracellular matrix