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硫酸乙酰肝素糖蛋白的结构-功能多样性与相关修饰酶群作用 被引量：7

The diversity of structure and function of heparin sulfate proteoglycans via modification of some relative enzymes
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摘要 The cytokine-receptor- heparin sulfate functional complex combined by cytokines, cytokine receptors, and heparin sulfate chains formed by concatenation of heparin sulfate proteoglycans (HSPG), an important component of extracellular matrix and modified by some relative enzymes, can regulate the density of cytokine receptors and their intracellular signal transduction. This article focused on the regulatory function of this complex. Many morphological abnormalities and diseases occur when the complex is dysfunctional. The cytokine-receptor- heparin sulfate functional complex combined by cytokines, cytokine receptors, and heparin sulfate chains formed by concatenation of heparin sulfate proteoglycans (HSPG), an important component of extracellular matrix and modified by some relative enzymes, can regulate the density of cytokine receptors and their intracellular signal transduction. This article focused on the regulatory function of this complex. Many morphological abnormalities and diseases occur when the complex is dysfunctional.
作者 姜笃银 付小兵 盛志勇
机构地区 解放军第
出处 《中国病理生理杂志》 CAS CSCD 北大核心 2005年第5期1020-1025,共6页 Chinese Journal of Pathophysiology
基金 国家重大基础研究规划资助项目(No.G1999054204) 国家自然科学基金面上项目(No.30170966) 国家自然科学基金重点项目(No.30230370)
关键词 类肝素硫酸蛋白聚糖 基膜 细胞外基质 Heparin sulfate proteoglycan Basement membrane Extracellular matrix
分类号 R363 [医药卫生—病理学]
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参考文献19

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二级参考文献8

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中国病理生理杂志
2005年 第5期

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