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应激相关的热休克信号转导通路的研究进展

Progress in stress-induced heat shock signaling pathways
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摘要 LI Yu-sheng, JIANG Yong (Department of Pathophysiology and Key Laboratory of Functional Proteomics of Guangdong Province, Southern Medical University, Guangzhou 510515, China) abtract:A lot of diseases (e.g., acute infarction and infections) and the diversity of harmful environmental changes, including elevating temperature, heavy metals and oxidants damage many kinds of proteins in organism. The denatured proteins usually evoke endogenous adaptive cellular mechanisms called heat shock response. After the activation, heat shock factors (HSFs) bind with heat shock element (HSE). This progress induces heat shock protein (HSP) expression, then facilitates repair of misfolded proteins, and finally inhibits the cell death (both necrosis and apoptosis) pathways. This review will introduce the structures and functions of HSF, HSP and HSE and details on the signaling process of HSP regulation by HSF. LI Yu-sheng, JIANG Yong (Department of Pathophysiology and Key Laboratory of Functional Proteomics of Guangdong Province, Southern Medical University, Guangzhou 510515, China) abtract:A lot of diseases (e.g., acute infarction and infections) and the diversity of harmful environmental changes, including elevating temperature, heavy metals and oxidants damage many kinds of proteins in organism. The denatured proteins usually evoke endogenous adaptive cellular mechanisms called heat shock response. After the activation, heat shock factors (HSFs) bind with heat shock element (HSE). This progress induces heat shock protein (HSP) expression, then facilitates repair of misfolded proteins, and finally inhibits the cell death (both necrosis and apoptosis) pathways. This review will introduce the structures and functions of HSF, HSP and HSE and details on the signaling process of HSP regulation by HSF.
作者 李煜生 姜勇
机构地区 南方医科大学病理生理学教研室和广东省功能蛋白质组学重点实验室
出处 《中国病理生理杂志》 CAS CSCD 北大核心 2005年第5期1030-1035,共6页 Chinese Journal of Pathophysiology
基金 国家杰出青年科学基金资助项目(No.39925014) 国家自然科学基金资助项目(No.30030060) 重大基础理论研究(973)计划项目(No.2002CB513000) 国家高技术研究发展计划(863)课题(No.2001AA234061)
关键词 热休克因子 热休克元件 热休克蛋白质类 信号转导 Heat shock factor Heat shock element Heat shock proteins Signal transduction
分类号 R363 [医药卫生—病理学]
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参考文献23

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中国病理生理杂志
2005年 第5期

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