摘要
LI Yu-sheng, JIANG Yong (Department of Pathophysiology and Key Laboratory of Functional Proteomics of Guangdong Province, Southern Medical University, Guangzhou 510515, China) abtract:A lot of diseases (e.g., acute infarction and infections) and the diversity of harmful environmental changes, including elevating temperature, heavy metals and oxidants damage many kinds of proteins in organism. The denatured proteins usually evoke endogenous adaptive cellular mechanisms called heat shock response. After the activation, heat shock factors (HSFs) bind with heat shock element (HSE). This progress induces heat shock protein (HSP) expression, then facilitates repair of misfolded proteins, and finally inhibits the cell death (both necrosis and apoptosis) pathways. This review will introduce the structures and functions of HSF, HSP and HSE and details on the signaling process of HSP regulation by HSF.
LI Yu-sheng, JIANG Yong (Department of Pathophysiology and Key Laboratory of Functional Proteomics of Guangdong Province, Southern Medical University, Guangzhou 510515, China) abtract:A lot of diseases (e.g., acute infarction and infections) and the diversity of harmful environmental changes, including elevating temperature, heavy metals and oxidants damage many kinds of proteins in organism. The denatured proteins usually evoke endogenous adaptive cellular mechanisms called heat shock response. After the activation, heat shock factors (HSFs) bind with heat shock element (HSE). This progress induces heat shock protein (HSP) expression, then facilitates repair of misfolded proteins, and finally inhibits the cell death (both necrosis and apoptosis) pathways. This review will introduce the structures and functions of HSF, HSP and HSE and details on the signaling process of HSP regulation by HSF.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2005年第5期1030-1035,共6页
Chinese Journal of Pathophysiology
基金
国家杰出青年科学基金资助项目(No.39925014)
国家自然科学基金资助项目(No.30030060)
重大基础理论研究(973)计划项目(No.2002CB513000)
国家高技术研究发展计划(863)课题(No.2001AA234061)
关键词
热休克因子
热休克元件
热休克蛋白质类
信号转导
Heat shock factor
Heat shock element
Heat shock proteins
Signal transduction