非动脉炎性前部缺血性视神经病变患者的血浆内皮素-1浓度的变化

Concentration of endothelin-1 of plasma in patients with nonarteritic anterior ischemic optic neuropathy

目的 观察非动脉炎性前部缺血性视神经病变(NAION)患者血浆内皮素- 1(ET -1) )浓度变化,探讨ET 1与NAION的关系。 方法 通过放射免疫法(RIA)测定41例NAION患者及年龄相匹配的15例非病变对照者血浆ET -1水平。将NAION患者按视盘水肿程度分为重度水肿组、轻度水肿组、水肿消退组3组;并根据病程分为发病14d内(病程1组)、15～3 0d(病程2组)、3 1～60d(病程3组)和61～180d(病程4组)等4组。对比分析不同性别、视盘水肿程度以及病程的NAION患者血浆ET- 1水平。 结果 NAION患者比对照者血浆ET 1水平增高(t =5 .0 2 ,P <0 .0 5 )。不同性别NAION患者血浆ET- 1水平无明显差异。视盘水肿程度不同组间血浆ET- 1水平差异有统计学意义(F =4.65 ,P <0 .0 5 ) ;血浆ET 1-水平随病程延长逐渐下降,不同病程组间血浆ET 1水平差异有统计学意义(F =4.2 9,P <0 .0 5 ) ;病程1、2、3组与对照组血浆ET 1水平比较,差异也有统计学意义(t1=5 .92 ,t2 =3 .47,t3 =2 .18,P1<0 .0 1,P2 <0 .0 5 ,P3 <0 .0 5 )。 结论 NAION患者血浆ET- 1水平可能与视盘损害程度和病程长短相关联。

Objective To observe the concentration of plasma endothelin (ET-1) in patients with nonarteritic anterior ischemic optic neuropathy(NAION) and investigate the relationship between ET-1 and NAION. Methods The plasma levels of ET-1 in 41 patients with NAION and 15 age-matched normal control subjects were measured by radioimmuoassay (RIA). The patients with NAION were divided into high papilloedema group, light papilloedema group, and recovery group according to the degree of papilloedema; and were divided into group1 (within 14 days), 2 (within 15-30 days), 3 (within 31-60 days), and 4 (within 61-180 days) according to the disease course. The plasma levels of ET-1 in different groups were detected and compared. Results The plasma level of ET-1 in patients with NAION was significantly higher than that in the normal subjects ( t=5.02,P <0.05)and there was no obvious difference in NAION patients with different genders.There were significant differences of the plasma level among the groups with different degree of papilloedema( F =4.65, P< 0.05). ET-1 plasma level gradually decreased as the disease course increased, and there were significant differences among the groups with different disease course( F =4.29, P< 0.05). The difference of plasma level of ET-1 between Group 1-3 with corresponding disease courses and the control group was significant respectively( t_1=5.92,t_2=3.47,t_3=2.18, P_1<0.01, P_2<0.05, P_3<0.05 ). Conclusion The plasma level of ET-1 in patients with NAION may be related to the degree of papilloedema lesion and disease courses.