摘要
目的探讨咬合支持丧失和重建对脑内神经生化代谢的影响。方法选取7例咬合支持长期丧失的患者,进行义齿修复以恢复咬合支持。于义齿修复前和义齿修复正常戴用6周后,应用质子磁共振波谱分析技术,检测患者海马内神经物质代谢的变化情况。结果恢复咬合支持6周后,7例患者胆碱复合物与肌酸的比值较义齿修复前平均下降11.9%(P<0.05);肌醇与肌酸的比值较义齿修复前平均下降28.8%(P<0.05);氮乙酰天门冬氨酸与肌酸的比值较义齿修复前上升4.8%(P>0.05)。结论恢复咬合支持6周后,患者脑内神经物质的变化趋势提示,恢复咬合支持可能有助于改善神经元功能。
Objective To study the effects of reconstruction of lost occlusal support on the biochemical changes of nervous system. Methods The changes of central nervous system metabolic compounds within hippocampus body were measured with proton magnetic resonance spectroscopy (1HMRS) before and after denture restoration (six weeks) in seven patients with prolonged loss of occlusal support. Results 1HMRS indicated that Cho/Cr decreased by 11.9% (P<0.05) six weeks after denture restoration, MI/Cr decreased by 28.8% (P<0.05), and NAA/CR increased by 4.8% (P>0.05) within hippocampus body. Conclusions Recovery of occlusal support facilitates improvement of neuron functions in patients′ hippocampus, which may help improve the functions of nervous system.
出处
《中华口腔医学杂志》
CAS
CSCD
北大核心
2005年第3期223-226,共4页
Chinese Journal of Stomatology
