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Transferrin receptor and Fc α/μ receptor may not be the major IgA_1 receptor on human mesangial cells 被引量：2

Transferrin receptor and Fc α/μ receptor may not be the major IgA_1 receptor on human mesangial cells
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摘要 IgA nephropathy (IgAN) is the most common form of primary glomerulonephritis. 1 The histopathology of IgAN is characterized by abundance of mesangial matrix and proliferation of mesangial cells. IgA_1 deposition in the mesangium plays an important role in the inflammatory process in this disease. IgA nephropathy (IgAN) is the most common form of primary glomerulonephritis. 1 The histopathology of IgAN is characterized by abundance of mesangial matrix and proliferation of mesangial cells. IgA_1 deposition in the mesangium plays an important role in the inflammatory process in this disease.
作者 HURui-hai ZHANGYing ZHAOMing-hui
机构地区 RenalDivisionandInstituteofNephrology
出处 《Chinese Medical Journal》 SCIE CAS CSCD 2005年第9期781-785,共5页 中华医学杂志（英文版）
基金 ThestudywassupportedbyNational"211 Project"inPekingUniversityandtheSpecialFundforPromotionofEducation MinistryofEducation China
关键词 immunoglobulin A . IgA nephropathy . mesangial cell . transferrin receptor . Fc α/μ receptor immunoglobulin A . IgA nephropathy . mesangial cell . transferrin receptor . Fc α/μ receptor
分类号 R692 [医药卫生—泌尿科学]
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参考文献10

  • 1GómezGuerreroC,GonzalezE,EgidoJ, etal.EvidenceforaspecificIgAreceptorinratandhumanmesangialcells[].JImmunol.1993
  • 2GómezGuerreroC,DuqueN,EgidoJ, etal.MesangialcellspossessanasialoglycoproteinreceptorwithaffinityforhumanimmunoglobulinA[].JAmSocNephrol.1998
  • 3DuqueN,GómezGuerreroC,EgidoJ, etal.InteractionofIgAwithFcalphareceptorsofhumanmesangialcellsactivatestranscriptionfactornuclearfactor kappaBandinducesexpressionandsynthesisofmonocytechemoattractantprotein1,IL 8, andIFN inducibleprotein[].JImmunol.1997
  • 4GómezGuerreroC,LopezArmadaMJ,GonzalezE, etal.SolubleIgAandIgGaggregatesarecatabolizedbyculturedratmesangialcellsandinduceproductionofTNF alphaandIL 6, andproliferation[].JImmunol.1994
  • 5LeungJC,TsangAW,ChanDT, etal.AbsenceofCD89, polymericimmunoglobulinreceptor, andasialoglycoproteinreceptoronhumanmesangialcells[].JAmSocNephrol.2000
  • 6CatchardG.Theattractionofproteinsforsmallmoleculesandions[].Annals of the New York Academy of Sciences.1991
  • 7IbelsLS,GyoryAZ,CatersonRJ, etal.PrimaryIgAnephropathy: naturehistoryandfactorsofimportanceintheprogressionofrenalimpairment[].Kidney International.1997
  • 8WesterhuisR,VanZandbergenG,VerhagenNA, etal.HumanmesangialcellsincultureandinkidneysectionsfailtoexpressFcαreceptor(CD89)[].JAmSocNephrol.1999
  • 9MouraIC,CentellesMN,MichelleAF, etal.Identificationofthetransferrinreceptorasanovelimmunoglobulin(Ig)A1 receptoranditsenhancedexpressiononmesangialcellsinIgAnephropathy[].The Journal of Experimental Medicine.2001
  • 10McDonaldKJ,CameronAngusJM,AllenJM, etal.ExpressionofFcα/μreceptorbyhumanmesangialcells:AcandidatereceptorforimmunocomplexdepositioninIgAnephropathy[].Biochemical and Biophysical Research Communications.2002

同被引文献5

  • 1杨蕾,李德芬,冯晓茵,陈汉文,杨忠,李正东,张荣泰,梁瑞安.重组抗B细胞淋巴瘤嵌合抗体的构建及鉴定[J].中国新药杂志,2006,15(3):186-192. 被引量：4
  • 2CESANO A, GAYKO U, BRANNAN C, et al. Differential Expression of CD22 in Indolent and Aggressive Non-Hodgkin's Lymphoma: Implieations for Targeted Immunotherapy [J]. Blood, 2002, 100: 350.
  • 3van HORSSEN PJ, van OOSTERHOUT Yv Jm, WITTET DE, et al. Cytotoxic Potency of CD22- Riein A Depends on Intracellular Routing Rather than on the Number of Internalized Molecules[J]. Scandinavian J Immunology, 1995, 41 (6): 563-569.
  • 4CATCHARD G. The Attraction of Proteins for Small Molecules and Ions[J]. Ann NY Acad Sci 1991, 51: 660-672.
  • 5ROSSMANN ED, LUNDIN J, LENKEI R, et al. Variability in B-cell Antigen Expression: Implications for the Treatment of B-Cell Lymphomas and Leukemias With Monoclonal Antibodies[J]. Hematol J, 2001, 2(5): 300-306.

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Chinese Medical Journal
2005年 第9期

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