P-gp、nm23和p53联合检测判断乳腺癌预后的价值

Expressions and Significance of P-gp,nm23 and p53 in Primary Breast Cancer Tissues

目的 研究乳腺癌组织中P-gp、nm23和p53的变化规律及与乳腺癌复发的关系.方法应用免疫组化方法检测10例乳腺纤维腺瘤(纤维腺瘤组)和47例乳腺癌病变组织中P-gp、nm23和p53 的表达,47例乳腺癌中18例随访3～5年无复发(无复发组),29例3年内复发(复发组),并比较其表达阳性率和表达强度的差异.结果乳腺癌复发组nm23表达阳性率较纤维腺瘤组低(P＜0.05),其阳性表达强度较无复发组低.复发组和无复发组p53表达阳性率均较纤维腺瘤组高(P＜0.05),复发组p53阳性表达强度高于无复发组(P＜0.05).复发组和无复发组P-gp表达阳性率与纤维腺瘤组比较差异无显著性意义,但其阳性表达强度较纤维腺瘤组低(P＜0.01,P＜0.025).结论 p53过表达和nm23低表达对预测乳腺癌复发具有一定价值.

Objective To study the expressions of P-gp, nm23 and p53 in primary breast cancer tissues and to evaluate the prediction significance in recurrence of the primary breast cancer. Methods Expressions of P-gp, nm23 and p53 in 57 benign and malignant breast paraffin-embedded specimens, the difference of the rate and intensity of positive reaction of P-gp,nm23 and p53 were checked by immunohistochemical staining.Results The positive rate of nm23 significantly increased in benign breast tissues compared with the tissues of recurrence of breast cancer. The positive intensity of nm23 was significantly decreased in the tissues of recurrence of breast cancer compared with the tissues of primary breast cancer. The positive rate of p53 was significantly increased in malignant breast tissues compared with benign breast tissues. The positive intensity of p53 was significantly increased in the tissues of recurrence of breast cancer compared with the tissues of primary breast cancer. There was no difference in the positive rate of P-gp in the tissue of recurrence and primary of breast cancer compared with benign breast tumor. But the positive intensity of P-gp was significantly decreased in the tissues of recurrence and primary of breast cancer compared with benign breast tumor. Conclusion The expression of p53 may indicate the proliferating activity of carcinoma cell. The positive intensity of expression of p53 and nm23 is valuable in prediction of the recurrence of primary breast cancer.