血培养阳性病原菌分布及变化趋势的临床分析

Clinical analysis of distribution and changing trend of pathogens in blood cultures

目的探讨血培养阳性病原菌的分布及变化趋势。方法分析2010份血培养标本中183株分离菌,并与临床资料进行对照。结果183株血培养阳性分离菌中,139株可确诊为血流感染的致病菌,占76.0%,其中革兰阳性球菌69株,占49.6%,革兰阴性杆菌57株,占41.0%,真菌13株,占9.4%。污染菌44株,占24.0%。139株致病菌中,主要致病菌有凝固酶阴性的葡萄球菌(CNS)40株,占28.8%,铜绿假单胞菌17株,占12.2%,大肠杆菌15株,占10.8%,真菌13株,占9.4%,金黄色葡萄球菌9株,占6.5%。结论血培养中病原菌以革兰阳性球菌为主,革兰阴性杆菌呈下降趋势。

Objective To find out the distribution and changing trend of pathogens in positive blood cultures. Methods To analyze 183 isolates from 2010 blood specimens then the results were compared with the relative clinical data. Results A total of 183 strains were isolated from all blood specimens, of which 139 strains (76.0%) were identified as pathogens, where 69 strains (49.6%)being Gram-positive cocci, 57 strains (41.0%) gram-negative bacilli, and 13 strains (9.4%) fungi, respectively. The other 44 strains (24.0%) were contaminated. The major pathogens in 139 strains were Coagulase-negative staphylococci (40 strains, 28.8%), Pseudomonas aeruginosa (17 strains, 12.2%), Escherichia coli (15 strains, 10.8%), fungi 13 strains (9.4%) and Staphylococcus aureus (9 strains, 6.5%). Conclusion The dominant pathogens in positive blood cultures were gram-positive cocci, while gram-negative bacilli cultures were becoming less.