基质金属蛋白酶抑制剂与肝纤维化
被引量：1
A Survey on the Relationship between MMPs-TIMPs and Liver Fibrosis
摘要
肝纤维化特征是细胞外基质(ECM)合成和降解失平衡的结果,ECM的降解受到严密调节,基质金属蛋白酶-基质金属蛋白酶抑制剂(MMPs -TIMPs)系统由于在降解ECM中起主要作用,而倍受重视。TIMPs家族中,TIMP - 1和TIMP - 2作为MMPs的抑制剂对MMP活性的调节起着关键作用,在肝硬化的形成和逆转过程中都起着重要作用。
出处
《农垦医学》
2005年第1期53-56,共4页
Journal of Nongken Medicine
参考文献26
-
1Williamson R A ,Marston F A ,Angal S.Disulphide bond assignment in human tissue inhibitor of metalloproteinases (TIMP) [J].Biochem J ,1990 ,268(2):267～274
-
2Murphy G ,Kokilitis P ,Carne A F.Dissociation of tissue inhibitor of metalloproteinases (TIMP) from enzyme complexes yields fully active inhibitor [J] Biochem J,1989,261(3):1031～1034
-
3Stetler-Sterenson W G ,Krutzsch H C ,Liota L A.Tissue inhibitor of metalloproteinase (TIMP-2):a new member of the metalloproteinase inhibitor family [J].J Biol Chem,1989,264 (29):17374～17378
-
4Pavloff N ,Staskus P W ,Kishnani N S.a new inhibitor of metalloproteinases from chicken :chIMP-3 N.a third member of the TIMP family[J].J Biol Chem ,1992,267(24):17321～17326
-
5Leco KJ ,Khokha R ,Pavloff N ,et al1 Tissue inhibitor of metallopro-teinases -3 (TIMP-3) is an extracellular matrix -associated protein with a distinctive pattern of expression in mouse cell and tissues.J Biol 1995～2003 Tsinghua Tongfang Optical Disc Co.,Ltd.All rights reserved.Chem,1994,269:9352～9360
-
6Apte SS ,Mattei MG ,Olsen BR.Cloning of the cDNA encoding human tissue inhibitor of metalloproteinases -3 (TIMP -3) and mapping of the TIMP -3 gene to chromosome 22.Genomics,1994,19:86～90
-
7Denhardt DT ,Feng B ,Edwards DR ,et al1 Tissue inhibitors of metal2 loproteinases (TIMP ,aka EPA) -structure ,control of expression and biological functions.Pharmacol Ther,1993,59:329～341
-
8Leco KJ ,Apte SS ,Taniguchi GT ,et al1 Murine tissue inhibitor of met2 alloproteinase -4 (TIMP -4):cDNA isolation and expression in adult mouse tissues.FEBS Lett ,1997,401:213～217
-
9Murphy G ,Docherty AJ P.The matrix metalloproteinases and their inhibitors.Am J Resp Cell Molec Biol ,1992,7:120～125
-
10Iredale J P,Murphy G,Hembry RM,et al1 Human hepatic lipocytes synthesize tissue inhibitor of metalloproteinases -1 (TIMP -1):Impli2 cations for regulation of matrix degradation in liver.J Clin Invest,1992,90:282～287
-
1佘正元,刘丽秋.基质金属蛋白酶及其组织抑制因子与糖尿病肾病[J].临床肾脏病杂志,2003,3(3):133-135. 被引量：2
-
2王占魁,姜慧卿.基质金属蛋白酶组织抑制因子与肝纤维化[J].国外医学（内科学分册）,2004,31(4):171-174. 被引量：1
-
3杨荣丽,唐立明,李兵兵.基质裂解素基因启动子5A／6A多态与急性心肌梗死的关系[J].中华老年多器官疾病杂志,2005,4(3):209-210.
-
4游绍莉,赵景民,辛绍杰,王松山,刘平,尹铁勇.实验性肝纤维化形成及逆转过程中膜性基质金属蛋白酶1mRNA表达的动态研究[J].解放军医学杂志,2001,26(6):407-409. 被引量：6
-
5金培彧,袁少飞,关敬之.瑞舒伐他汀对于心肌肥厚大鼠的作用及机制研究[J].中外医疗,2014,33(17):127-128.
-
6段珊,邓立普.基质金属蛋白酶及其抑制物在慢性阻塞性肺疾病中的相关研究[J].现代医药卫生,2007,23(22):3391-3393. 被引量：1
-
7罗新栋,聂青和.金属蛋白酶组织抑制因子在肝纤维化研究中的价值[J].肝脏,2003,8(2):40-42. 被引量：25
-
8游绍莉,赵景民,辛绍杰,王松山,刘平,尹铁勇.实验性肝纤维化形成及逆转过程中膜性基质金属蛋白酶-1 mRNA表达的动态研究[J].传染病信息,2001,14(2):74-75. 被引量：2
-
9王相智.尼群地平逆转高血压左心室肥厚的观察[J].徐州医学院学报,1995,15(1):86-87. 被引量：1
-
10赵春洪,张晓岚.MMPs在肝纤维化形成与逆转过程中的作用[J].临床肝胆病杂志,2009,25(3):231-235. 被引量：4
