摘要
目的 观察内毒素血症时大鼠颈迷走神经传出放电的变化。方法 SD大鼠随机分为两组:内毒素组静脉注射内毒素5mg/kg ;对照组注射等容量生理盐水。应用神经电生理技术,记录并分析内毒素注射后3 0min、1、2、4h颈迷走神经传出放电频率的改变。结果 两组基础放电差异无显著性意义(P >0 0 5 )。大鼠注射内毒素后各时间点放电频率明显升高,与基础放电及注射生理盐水组的对应时间点相比,差异有显著性意义(P <0 0 5 )。结论 内毒素血症时颈迷走神经传出活动增强,这种改变可能是机体发挥其内源性抗炎保护作用的途径之一。
Objective To investigate the changes of cervical vagal efferent discharge induced by lipopolysaccaride in rats. Methods Ten rats were randomly divided into two groups, receiving lipopolysaccaride (5 mg/kg) or normal saline through intravenous injection. Frequency of cervical vagal efferent discharge was recorded at 30 min, 1, 2 and 4 h after the injection. Results The frequency of cervical vagal efferent discharge was significantly increased after LPS injection (P<0.05) while no significant changes after saline injection. Conclusion LPS enhanced the activation of cervical vagal efferent discharge. Vagus might play an important role when systemic inflammatory response syndrome occurs.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
2005年第9期850-852,共3页
Journal of Third Military Medical University
关键词
迷走神经
内毒素血症
传出放电
vagus nerve
lipopolysaccaride
efferent discharge
