摘要
在超负荷心肌肥厚过程中存在心肌细胞的凋亡和增殖,心肌细胞的凋亡可能是代偿性肥厚向心衰转变的决定因素,凋亡的发生机制涉及外在因素和一些内源性细胞通路。另一方面,心肌肥厚中既有心肌细胞的肥大,亦存在心肌细胞的增殖,心肌细胞的增殖与细胞周期素(Cyclin)、细胞周期依赖激酶(Cdk)、Cdk抑制因子(CdkI)、bcl2、p53及端粒等因子有关,心肌细胞的凋亡和增殖通过一些因子相关联。
s:Cardiomyocyte apoptosis and regeneration are present in overload cardiac hypertrophy. Cardiac myocyte apoptosis might be a critical factor during the transition from compensatory hypertrophy to heart failure. The mechanisms of apoptosis include extrinsic factors and some cellular signal pathways. On the other hand, cardiomyocyte hyperplasia, as well as hypertrophy, contributes to cardiac hypertrophy. Caridomyocyte regeneration is related to cyclin, cyclin dependent kinase (Cdk), Cdk inhibitors (CdkI), bcl-2, p53 and telomere. Cardiaomyocyte regeneration and apoptosis are linked through several factors.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2005年第5期531-535,共5页
Chinese Pharmacological Bulletin
关键词
心肌肥厚
心肌细胞
增殖
凋亡
cardiac hypertrophy
cardiomyocyte
regeneration
apoptosis
