神经生化标志物S100β蛋白研究进展

The Research Progression of S100β as a Neurochemistry Maker

S100β是一类钙离子结合蛋白,是轴突的生长因子,由神经系统胶质细胞分泌,广泛分布于神经组织中,在正常情况下发挥重要的生理作用,但分泌过高具有神经毒性。脑损伤后血清中S100β水平有时间的规律性,并与脑损伤程度有密切关系,可以作为脑损伤后神经生化新标识物。本文综述了近年来的S100β蛋白的分子生物学基础、神经生理作用及其在神经组织损伤、疾病中的作用机制。

S100β is one kind of the calcium binding proteins. As growth factor of neuraxon, it is excreted by neuroglial cell, and distributing in nerve tissue extensively. Although S100β has very important values neurophysiological, it also has neurotoxicity with excreting overmuch. Concentration of S100β changes regularity in serum after the brain injury. In addition, it has a close relations with the degree of brain damage, which can be regarded as the neural new marker of biochemistry after brain damage. The advances of S100β protein, in the research on neurophysiological values and its application for nerve tissue injury, disease were reviewed.